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Dexmedetomidine decreases perioperative myocardial lactate release in dogs

Dexmedetomidine decreases perioperative myocardial lactate release in dogs

Anesthesia and Analgesia 96(3): 657-664

ISSN/ISBN: 0003-2999

PMID: 12598239

DOI: 10.1213/01.ane.0000048708.75957.ff

The sympatholytic effect of the alpha 2-adrenergic agonist dexmedetomidine may decrease emergence-related myocardial ischemic load in patients. However, a direct measure of myocardial ischemia, such as myocardial lactate release, is difficult to obtain in patients. Therefore, we studied mongrel dogs and measured myocardial lactate release, myocardial oxygen supply, hemodynamic variables, and neurohumoral indices of the stress response.

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Accession: 003710739

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