EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Dietary induction of angiotensin-converting enzyme in proximal and distal rat small intestine


Dietary induction of angiotensin-converting enzyme in proximal and distal rat small intestine



American Journal of Physiology. Gastrointestinal and Liver Physiology 281(5): G1221-G1227



ISSN/ISBN: 0193-1857

PMID: 11668031

Induction of angiotensin-converting enzyme was examined in proximal and distal intestinal segments of rats fed a low-protein (4%) diet and then switched to a high-protein (gelatin) diet. Animals were killed at varying time points, and brush-border membranes and total RNA were prepared from the segments. In the proximal intestine, there was a fivefold increase in angiotensin-converting enzyme levels after 14 days but only a twofold change in mRNA. In the distal intestine, there was no increase in enzyme activity but mRNA increased 2.4-fold. Organ culture was used to measure changes in enzyme biosynthesis. There was a 5- to 6-fold increase in the biosynthesis of angiotensin-converting enzyme in the proximal intestine 24 h after the switch to the gelatin diet and a 1.6-fold increase in mRNA levels. No change in biosynthesis was observed in the distal small intestine despite an increase in mRNA. These results support the conclusion that rapid dietary induction of intestinal angiotensin-converting enzyme is differentially regulated in proximal and distal segments of the small intestine. Reprinted by permission of the publisher.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 003712156

Download citation: RISBibTeXText

Related references

Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension 60(3): 730-740, 2012

Induction of angiotensin converting enzyme with the angiotensin converting enzyme inhibitory compound mk 421 n s 1 ethoxycarbonyl 3 phenylpropyl l alanyl l proline in rat lung. European Journal of Pharmacology 80(1): 121-126, 1982

Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. Shock 43(4): 395-404, 2015

Angiotensin converting enzyme in brush-border membranes of avian small intestine. Journal of Experimental Biology 135: 1-8, 1988

Angiotensin-converting enzyme (ACE) inhibitor-associated angioedema of the stomach and small intestine: a case report. Mount Sinai Journal of Medicine new York 73(8): 1123-1125, 2006

Purification and characterization of angiotensin converting enzyme from rat small intestine and its role in protein digestion. Gastroenterology 98(5 Part 2): A411, 1990

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2. Frontiers in Pharmacology 11: 920, 2020

Angiotensin-converting enzyme of the human small intestine. Subunit and quaternary structure, biosynthesis and membrane association. Biochemical Journal 286: 451-457, 1992

A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane. Biochemistry 47(32): 8335-8341, 2008

Induction of cardiac angiotensin I-converting enzyme with dietary NaCl-loading in genetically hypertensive and normotensive rats. Journal of Molecular Medicine 73(5): 243-248, 1995

Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension 58(2): 182-189, 2011

Rapid induction of rat small intestinal angiotensin-converting enzyme and dipeptidyl aminopeptidase IV by a high proline diet. Gastroenterology 104(4 Suppl): A655, 1993

Brush-border membrane lactase: purification and kinetic analysis of two forms of the enzyme from the proximal and distal small intestine of suckling rats. Biochemical Society Transactions 7(5): 961-962, 1979

Biosynthesis of rat small intestinal brush border membrane angiotensin-converting enzyme during induction by a high proline diet. Gastroenterology 108(4 Suppl): A725, 1995

High dietary sodium blunts affects of angiotensin-converting enzyme inhibition on vascular angiotensin I-to-angiotensin II conversion in rats. Journal of Cardiovascular Pharmacology 42(5): 601-606, 2003