EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats


Dietary nucleotide supplementation reduces thioacetamide-induced liver fibrosis in rats



Journal of Nutrition 132(4): 652-657



ISSN/ISBN: 0022-3166

PMID: 11925456

DOI: 10.1093/jn/132.4.652

Dietary nucleotides reportedly promote functionality and repair in fibrotic liver. Liver fibrosis is characterized by an excessive accumulation of extracellular matrix components, which lead to the impairment of the hepatic function. The aim of this work was to evaluate the influence of dietary nucleotides on liver fibrosis induced by thioacetamide and to elucidate the mechanism by which nucleotides exert their protective effects. Rats consumed ad libitum 300 mg/L thioacetamide in drinking water and were pair-fed diets with (group TN) or without nucleotides (group TS) for 4 mo. Liver histology and extracellular matrix components, liver collagenase and prolyl 4-hydroxylase activities, and tissue inhibitor of metalloproteinases-1 were assessed. The degree of fibrosis was lower in group TN than in group TS. Group TN had lower hepatic concentration of hydroxyproline (P < 0.05), collagen type I (P = 0.12) and type III (P = 0.20), fibronectin (P = 0.05), laminin (P = 0.11) and desmin (P = 0.07), higher collagenolytic activity (P < 0.05), lower prolyl 4-hydroxylase activity (P < 0.05) and lower prolyl 4-hydroxylase (P = 0.10) and tissue inhibitor of metalloproteinase-1 (P = 0.06) expression than group TS. Moreover, expression of tissue inhibitor of the metalloproteinases-1 gene was lower in group TN than in group TS (P < 0.05). These data indicate that the reduction of liver fibrosis in nucleotide-supplemented rats may rely on the enhancement of collagenase activity and the reduction of collagen content and maturation. Reprinted by permission of the publisher.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003712338

Download citation: RISBibTeXText

Related references

Dabigatran Reduces Liver Fibrosis in Thioacetamide-Injured Rats. Digestive Diseases and Sciences 64(1): 102-112, 2019

Dietary supplementation with monounsaturated and long-chain polyunsaturated fatty acids influences the liver structural recovery and hepatocyte binuclearity in female Wistar rats in experimental cirrhosis induced by thioacetamide. Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft für Toxikologische Pathologie 57(1): 65-75, 2005

Puerarin alleviates liver fibrosis via inhibition of the ERK1/2 signaling pathway in thioacetamide-induced hepatic fibrosis in rats. Experimental and Therapeutic Medicine 18(1): 133-138, 2019

Effect of dietary supplementation of grape skin and seeds on liver fibrosis induced by dimethylnitrosamine in rats. Nutrition Research and Practice 4(5): 369-374, 2010

On the biochemistry of liver connective tissue during the development of liver fibrosis induced in rats by thioacetamide. Acta Hepato-Splenologica 8: 102-109, 1961

Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats. Human and Experimental Toxicology 2020: 960327120947453, 2020

Protective effects of melatonin against thioacetamide-induced liver fibrosis in rats. Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society 66(4): 567-579, 2015

Soy isoflavone delays the progression of thioacetamide-induced liver fibrosis in rats. Scandinavian Journal of Gastroenterology 46(3): 341-349, 2011

Polaprezinc prevents ongoing thioacetamide-induced liver fibrosis in rats. Life Sciences 90(3-4): 122-130, 2012

Enalapril to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 36(4 Part 2): 487A, 2002

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 33(2): 379-386, 2001

Dietary α-Lactalbumin protects against thioacetamide-induced liver cirrhosis by maintaining gut-liver axis function in rats. Bioscience Biotechnology and Biochemistry 84(1): 171-177, 2020

Lactoferrin Enhanced Apoptosis and Protected Against Thioacetamide-Induced Liver Fibrosis in Rats. Open Access Macedonian Journal of Medical Sciences 3(2): 195-201, 2015

Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats. Laboratory Investigation; a Journal of Technical Methods and Pathology 88(6): 627-633, 2008

Effect of Basil Leaves Extract on Liver Fibrosis Induced by Thioacetamide in Male Rats. International Journal of Pharmacology 15(4): 478-485, 2019