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Dietary potassium and laxatives as regulators of colonic potassium secretion in end-stage renal disease

Dietary potassium and laxatives as regulators of colonic potassium secretion in end-stage renal disease

Nephrology Dialysis Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association 18(2): 341-347

ISSN/ISBN: 0931-0509

PMID: 12543890

DOI: 10.1093/ndt/18.2.341

Background. In end-stage renal disease (ESRD), colonic potassium (K+) secretion increases as renal K+ excretion declines. The nature of this adaptive process is poorly understood, but post-prandial increases in plasma K+ concentration may be a determining factor. In addition, even though colonic K+ secretion increases in ESRD, interdialytic hyperkalaemia is a serious problem in haemodialysis patients, which might be reduced by stimulating colonic K+ secretion still further using laxatives.

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Accession: 003712407

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