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Differential effects of leptin on cancer in vitro

Differential effects of leptin on cancer in vitro

Journal of Surgical Research 113(1): 50-55

ISSN/ISBN: 0022-4804

PMID: 12943810

DOI: 10.1016/s0022-4804(03)00166-5

Introduction: Leptin, a protein produced by adipocytes, is an important signaling molecule in energy regulation and food intake. Many obese patients have leptin resistance associated with increased circulating leptin. Leptin receptor activation downregulates many regulatory genes, including STAT-3 and PAP 1. Certain cancers are associated with obesity, including breast, prostate, and colon. Recent studies have shown that leptin stimulates proliferation of human colon cancer in vitro.

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Accession: 003713421

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