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Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression

Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression

Journal of Investigative Dermatology 119(3): 583-589

ISSN/ISBN: 0022-202X

PMID: 12230499

DOI: 10.1046/j.1523-1747.2002.00116.x

The effects of 1,25-dihydroxyvitamin D3 on the differentiation of immature melanocyte precursors were studied. The NCC-/melb4 cell line is an immature melanocyte cell line established from mouse neural crest cells. 1,25-dihydroxyvitamin D3 inhibited the growth of NCC-/melb4 cells at concentrations higher than 10-8 M. Growth inhibition was accompanied by the induction of tyrosinase and a change in L-3,4-dihydroxyphenylalanine reactivity from negative to positive.

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Accession: 003714008

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