EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Disodium cromoglycate prevents ileum hyperreactivity to histamine in Toxocara canis-infected guinea pigs


Disodium cromoglycate prevents ileum hyperreactivity to histamine in Toxocara canis-infected guinea pigs



Pharmacological Research 48(5): 451-455



ISSN/ISBN: 1043-6618

PMID: 12967589

DOI: 10.1016/s1043-6618(03)00208-1

The aim of this study was to investigate whether Toxocara canis infection in guinea pigs provokes changes in ileum responsiveness to histamine. Ileum segments from control and T. canis-infected groups were placed at isometric conditions and submitted to various doses of histamine. No changes were observed between controls and T. canis-infected groups at days 3, 6 and 12 after infection. However, at days 18 and 24 after infection, there was a significant increase in ileum responsiveness to histamine in T. canis-infected group. Pre-incubation of ileum segments with 1mgml(-1) disodium cromoglycate (DSCG) prevented the increased responsiveness to histamine in T. canis-infected guinea pigs and did not affect ileum contractility in non-infected animals. These results indicate that T. canis-infected guinea pigs develop increased intestinal responsiveness to histamine and that DSCG prevents alterations in smooth-muscle contractility.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003715441

Download citation: RISBibTeXText

Related references

Ultrasonically nebulized distilled water prevents exogenous histamine hyperreactivity in Toxocara canis-infected mice. Inflammation Research: Official Journal of the European Histamine Research Society . 54(6): 243-248, 2005

Effect of disodium cromoglycate and Picrorhiza kurroa root powder on sensitivity of guinea pigs to histamine and sympathomimetic amines. International Archives of Allergy and Applied Immunology 53(2): 137-144, 1977

Immediate hypersensitivity responses in guinea pigs infected with Toxocara canis or Trichinella spiralis. J PARASITOL 50(3 Sect 2): 24-25, 1964

Toxocara pteropodis toxocara canis and toxocara cati infections in guinea pigs. Tropical Biomedicine 3(2): 97-106, 1986

Immediate hypersensitivity and serological responses in guinea pigs infected with Toxocara canis or Trichinella spiralis. American Journal of Tropical Medicine and Hygiene 14(6): 1044-1051, 1965

Amebic invasion of the liver of guinea pigs infected with the larvae of a nematode, Toxocara canis. Experimental Parasitology 5(5): 421-426, 1956

Amebic invasion of the liver of guinea pigs infected with the larvae of the nematode, Toxocara canis. Experimental Parasitology 5: 421-26, 1956

Further studies on the effects of disodium cromoglycate on guinea pig ileum. Agents and Actions 12(5-6): 596-600, 1982

The comparison of counterimmunoelectrophoresis with indirect haemagglutination test for detection of antibodies in experimentally infected guinea pigs with Toxocara canis. Journal of Helminthology 51(2): 143-148, 1977

Effects of disodium cromoglycate (DSCG) on the guinea pig trachea and ileum. Allergologia et Immunopathologia 11(6): 425-430, 1983

A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulants. Agents and Actions 10(1 Pt 2): 8-14, 1980

Localization of Toxocara canis larvae in the diaphragm of experimentally infected guinea-pigs. Differentiation from trichin-ella larvae.. Ann. Fac. Med. vet, Pisa 15: 118-126, 1963

Specificity and sensitivity of skin test reactions to extracts of Toxocara canis and Ascaris suum. I. Skin tests done on infected guinea pigs. American Journal of Tropical Medicine and Hygiene 24(3): 455-459, 1975

Specificity and sensitivity of skin test reactions to extracts of Toxocara canis and Ascaris suum II. Homologous 48-hour passive cutaneous anaphylaxis tests with sera from infected guinea pigs. American Journal of Tropical Medicine and Hygiene 24(3): 460-464, 1975

Spontaneous and evoked histamine release from guinea pig skin in vitro in presence of disodium cromoglycate. International Archives of Allergy and Applied Immunology 43(3): 390-394, 1972