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Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice


Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice



Journal of Endocrinology 174(2): 273-281



ISSN/ISBN: 0022-0795

PMID: 12176666

DOI: 10.1677/joe.0.1740273

Bombesin (BN) interacts with two mammalian receptor subtypes termed gastrin-releasing peptide (GRP)-preferring (GRP-R) and neuromedin B (NMB)-preferring (NMB-R) that may mediate the satiety action of BN. We examined the feeding behaviour of mice that were deficient in the GRP-R (GRP-R KO) to assess the overall contribution of this receptor subtype in the feeding actions of BN-related peptides.

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Accession: 003715681

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