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Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?

Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?

Archives of Toxicology 77(6): 313-320

ISSN/ISBN: 0340-5761

PMID: 12669189

DOI: 10.1007/s00204-003-0452-0

Phosphorothioate compounds are widely used in agriculture and public health for the control of unwanted pests. The phosphorothioate parathion was metabolised to the toxic metabolite paraoxon (0.038-0.683 nmol/min per mg protein) and p-nitrophenol (0.023-2.10 nmol/min per mg protein) by human liver microsomes (n=27) in an NADPH-dependent reaction.

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Accession: 003717759

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