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Does L-canavanine ingestion induce murine SLE? Paradoxical effects on survival of BALB/c mice


Does L-canavanine ingestion induce murine SLE? Paradoxical effects on survival of BALB/c mice



Journal of Nutritional Immunology 5(3/4): 17-27



Observations in humans and macaques suggest that ingestion of an excess of lucerne sprouts can induce systemic lupus erythematosus (SLE). Feeding L-canavanine increased the incidence of autoimmune symptoms in several strains of mice. The presence of L-canavanine in lucerne sprouts could result in the synthesis of proteins rich in L-canavanyl residues and subsequent recognition of these modified endogenous proteins as foreign.

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