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Domain and genomic sequence analysis of bdellin-KL, a leech-derived trypsin-plasmin inhibitor


Domain and genomic sequence analysis of bdellin-KL, a leech-derived trypsin-plasmin inhibitor



Journal of Biochemistry 130(3): 431-438



ISSN/ISBN: 0021-924X

PMID: 11530020

DOI: 10.1093/oxfordjournals.jbchem.a003003

Bdellin-KL is a trypsin-plasmin inhibitor from Hirudo nipponia, whose N-terminal sequence was identified as a non-classical Kazal-type. A cDNA clone encoding the inhibitor was isolated by reverse transcription-PCR and 5' rapid amplification of cDNA ends. The cDNA showed an open reading frame of 155 amino acids comprising one signal peptide and two separated domains. The C-terminal domain consists of distinct internal repeats, including HHEE and HHDD.

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Accession: 003718292

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