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Effect of Leweifang on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin

Effect of Leweifang on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin

Korean Journal of Pharmacognosy 33(1): 13-17

H. pylori infection is associated with type B gastritis, peptic ulcer and gastric cancer. The vacuolation of cells induced by H. pylori is thought to be essential for the initiation and maintenance of gastric infection. The roles of H. pylori cytotoxin, urease and ammonia in the vacuolation of HeLa cells were determined. Ammonium chloride augmented the neutral red uptake induced by H. pylori toxin. Acetohydroxamic acid (AHA) failed to block the neutral red uptake induced by H. pylori toxin.

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