EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells


Effect of Perilla frutescens on nitric oxide production and DNA synthesis in cultured murine vascular smooth muscle cells



PhytoTherapy Research: Ptr 16(Suppl): S19-S23



ISSN/ISBN: 0951-418X

PMID: 11933134

DOI: 10.1002/ptr.781

The effects of perilla (Perilla frutescens, Labiatae) on murine cultured vascular smooth muscle cells (VSMC) were investigated. The water extract of perilla leaves induced nitric oxide (NO) production of VSMC and this effect was synergistically augmented when combined with interferon (IFN)-gamma or tumour necrosis factor (TNF)-alpha, while the perilla extract significantly inhibited NO production induced by IFN-gamma combined with lipopolysaccharide (LPS). Northern blot analysis revealed that these effects of the perilla extract paralleled mRNA expression of inducible nitric oxide synthase. However, the perilla extract significantly inhibited platelet derived growth factor (PDGF) or TNF-alpha-induced VSMC proliferation measured as DNA synthesis. The inhibitory effect of the perilla extract on TNF-alpha-induced VSMC proliferation was significantly suppressed by N(G)-monomethyl-L-arginine, a non-specific nitric synthase inhibitor, suggesting that this effect was partially mediated by NO production as an autocrine/paracrine factor. The present findings suggest that perilla would be useful for the prevention of vascular diseases such as arteriosclerosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003723943

Download citation: RISBibTeXText

Related references

Effect of Perilla frutescens extract on nitric oxide production by cultured murine mesangial cells. Biological and Pharmaceutical Bulletin 22(5): 476-480, 1999

Insulin-like growth factor I inhibits the production of nitric oxide evoked by the inducible nitric oxide synthase in cultured vascular smooth muscle cells. FASEB Journal 7(3-4): A243, 1993

Effect of interleukin-1 receptor antagonist on the induction of nitric oxide production by interleukin-1-alpha in cultured rat vascular smooth muscle cells. Dokkyo Journal of Medical Sciences 21(2): 157-162, 1994

Amlodipine increases nitric oxide synthesis in cytokine-stimulated cultured vascualar smooth muscle cells. Journal of Hypertension 18(11): 1597-1604, 2000

Dipyridamole enhanced IL-1-beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. Journal of the American Society of Nephrology 6(3): 663, 1995

Nitric Oxide Generators Inhibit Total Protein and Collagen Synthesis in Cultured Vascular Smooth Muscle Cells. Circulation 90(4 Part 2): I627, 1994

Atrial natriuretic peptide enhances IL-1b stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Journal of the American Society of Nephrology 7(9): 1566, 1996

Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. European Journal of Pharmacology 296(3): 319-326, 1996

Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circulation Research 76(2): 305-309, 1995

Eicosapentaenoic acid potentiates the production of nitric oxide evoked by interleukin-1 beta in cultured vascular smooth muscle cells. Journal of Vascular Research 30(4): 209-217, 1993

Atrial natriuretic peptide enhances IL-1 beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Kidney and Blood Pressure Research 21(1): 36-41, 1998

Arginine vasopressin inhibits interleukin-1b stimulated nitric oxide production via V1 receptor in cultured rat vascular smooth muscle cells. Journal of the American Society of Nephrology 7(9): 1566, 1996

Cyclosporin A and FK506 suppress nitric oxide production by a murine macrophage cell line J774 and rat vascular smooth muscle cells. Moncada, S, Feelisch, M, Busse, R, Higgs, E A Portland Press Proceedings; The biology of nitric oxide, Vol 4 Enzymology, biochemistry and immunology 479-484, 1994

Insulin raises the redox potential of cultured vascular smooth muscle cells which stimulates nitric oxide -dependent cyclic GMP production. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 334A-335A, 2000

Insulin stimulates nitric oxide -dependent cyclic GMP production in cultured vascular smooth muscle cells by raising the redox potential. Circulation 102(18 Suppl): II 128, 2000