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Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7


Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7



Toxicology and Applied Pharmacology 168(1): 64-71



ISSN/ISBN: 0041-008X

PMID: 11000101

DOI: 10.1006/taap.2000.9001

The mode of action of pycnogenol (PYC), extracted from the bark of Pinus maritima on lipopolysaccharide (LPS)-induced interleukin-1 beta (IL-1 beta ) gene expression was studied. Results demonstrated that PYC blocks both nuclear factor kappa B and activated protein-1 activation in LPS-stimulated RAW 264.7 cells.

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Accession: 003725167

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