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Effect of different level of conjugated linoleic acid on apoptosis of colonic mucosal cell and biomarkers in colon cancer of 1,2-dimethylhydrazine-treated rats



Effect of different level of conjugated linoleic acid on apoptosis of colonic mucosal cell and biomarkers in colon cancer of 1,2-dimethylhydrazine-treated rats



Korean Journal of Nutrition 35(5): 505-511



The anticarcinogenic effects of different levels of conjugated linoleic acid (CLA) in 1,2-dimethylhydrazine (DMH)-treated rats were investigated by determining biomarkers (apoptosis, cell proliferation, eicosanoids and 1,2-diacylglycerol) and phospholipid fatty acid profile in colonic mucosa. 80 male Sprague-Dawley rats weighing 180-220 g were randomly divided into 4 groups depending on CLA content: 0.0, 0.5, 1.0 and 1.5% CLA.

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