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Effect of dl-praeruptorin A on ATP sensitive potassium channels in human cortical neurons

Effect of dl-praeruptorin A on ATP sensitive potassium channels in human cortical neurons

Acta Pharmacologica Sinica 22(9): 813-816

Objective: To investigate the effect of dl-praeruptorin A (Pd-Ia; a component of Baihua Qianhu (Peucedanum praeruptorum)) on ATP sensitive potassium channels (KATP channel) in human cortical neurons. Methodology: Standard whole cell recording method was used. Cell membranes were held at -40 mV, the commanding potential was -30 to +100 mV and duration was 600 ms. Results: Pd-Ia activated KATP channels in human cortical neurons in a concentration-dependent manner.

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Accession: 003727441

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PMID: 11749862

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