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Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters

Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters

Journal of Acquired Immune Deficiency Syndromes 26(5): 405-412

Fits of mathematical models to the decline in HIV-1 RNA after antiretroviral therapies have yielded estimates for the life span of productively infected cells of 1 to 2 days. In a previous report, we described the mathematical properties of an extended model that accounts for imperfect viral suppression and the eclipse phase of the viral life cycle (the intracellular delay between initial infection and release of progeny virions).

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Accession: 003727541

Download citation: RISBibTeXText

PMID: 11391159

DOI: 10.1097/00042560-200104150-00002

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