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Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans



Effect of enteral vs. parenteral glucose delivery on initial splanchnic glucose uptake in nondiabetic humans



American Journal of Physiology. Endocrinology and Metabolism 283(2): E259-E266



To determine if enteral delivery of glucose influences splanchnic glucose metabolism, 10 subjects were studied when glucose was either infused into the duodenum at a rate of 22 mmol kg-1 min-1 and supplemental glucose given intravenously or when all glucose was infused intravenously while saline was infused intraduodenally. Hormone secretion was inhibited with somatostatin, and glucose ([similar]8.5 mmol/l) and insulin ([similar]450 pmol/l) were maintained at constant but elevated levels. Intravenously infused [6,6-2H2]glucose was used to trace the systemic appearance of intraduodenally infused [3-3H]glucose, whereas UDP-glucose flux (an index of hepatic glycogen synthesis) was measured using the acetaminophen glucuronide method. Despite differences in the route of glucose delivery, glucose production (3.5 [plus or minus] 1.0 vs.3.3 [plus or minus] 1.0 mmol kg-1 min-1) and glucose disappearance (78.9 [plus or minus] 5.7 vs. 85.0 [plus or minus] 7.2 mmol kg-1 min-1) were comparable on intraduodenal and intravenous study days. Initial splanchnic glucose extraction (17.5 [plus or minus] 4.4 vs. 14.5 [plus or minus] 2.9%) and hepatic UDP-glucose flux (9.0 [plus or minus] 2.0 vs. 10.3 [plus or minus] 1.5 mmol kg-1 min-1) also did not differ on the intraduodenal and intravenous study days. These data argue against the existence of an "enteric" factor that directly (i.e., independently of circulating hormone concentrations) enhances splanchnic glucose uptake or hepatic glycogen synthesis in nondiabetic humans. Reprinted by permission of the publisher.

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Accession: 003727751

Download citation: RISBibTeXText

PMID: 12110530

DOI: 10.1152/ajpendo.00178.2001



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