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Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa

Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa

Journal of Immunology 169(2): 818-828

In chickens, a single set of unique functional segments of both Ig H and L chain genes is rearranged during early embryogenesis to generate a pool of B cell progenitors that will be diversified in the bursa by gene conversion, forming the preimmune repertoire. After hatching, bursal cells are exposed to environmental Ags in the bursal lumen.

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Accession: 003727768

Download citation: RISBibTeXText

PMID: 12097385

DOI: 10.4049/jimmunol.169.2.818

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