+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function

Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function

British Journal of Nutrition 89(5): 607-616

ISSN/ISBN: 0007-1145

PMID: 12720581

DOI: 10.1079/bjn2003820

There has been much recent interest in the cardiovascular benefits of dietary isoflavones. The aim of the present in vitro studies was to investigate potential anti-thrombogenic and anti-atherogenic effects of the isoflavones genistein and daidzein in platelets, macrophages and endothelial cells. Pre-treatment with either isoflavone inhibited collagen-induced platelet aggregation in a dose-dependent manner. In a macrophage cell line (RAW 264.7) activated with interferon gamma plus lipopolysaccharide, both isoflavones were found to inhibit NO production and tumour necrosis factor alpha (TNF-alpha) secretion dose-dependently, but they did not affect mRNA levels for inducible nitric oxide synthase and cyclo-oxygenase-2. Both isoflavones also dose-dependently decreased monocyte chemoattractant protein-1 secretion induced by TNF-alpha in human umbilical vein endothelial cells. Compared with daidzein, genistein exerted greater inhibitory effects for all parameters studied. The present data contributes to our knowledge on the molecular mechanisms by which isoflavones may protect against coronary artery disease. Further studies are required to determine whether the effects of isoflavones observed in the current in vitro studies are relevant to the aetiology of coronary artery disease in vivo.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003728900

Download citation: RISBibTeXText

Related references

Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function. Biochimica et Biophysica Acta 1670(3): 229-237, 2004

Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adults. Physiological Reports 5(10): E13189, 2017

Relationship between monocyte-platelet aggregation and endothelial function in middle-aged and elderly adults. Physiological Reports 5(10): E13189, 2017

A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. Journal of Nutrition 126(8): 2000-2006, 1996

Effect of daidzein and genistein on immune function in mice. Yakhak Hoeji 44(2): 182-188, 2000

The Sensitivity of Whole Blood Aggregation, Platelet Rich Plasma Aggregation and Platelet Function Analyzer in Detecting Aspirin Effect on Platelet Function. Blood 100(11): Abstract No. 3819, 2002

Acidic peptides enhanced genistein-dependent inhibition of human platelet aggregation: potential protective effect of digestible peptides plus genistein against atherosclerosis. Nutrition Research 28(8): 523-531, 2008

The effect of initiation of antiretroviral therapy on monocyte, endothelial and platelet function in HIV-1 infection. HIV Medicine 16(10): 608-619, 2015

Inhibitory effects of lipoteichoic acid from Staphylococcus aureus on platelet function and platelet-monocyte aggregation. Inflammation Research: Official Journal of the European Histamine Research Society . 60(8): 775-782, 2011

The presence of monoiodinated derivates of daidzein and genistein in human urine and its effect on thyroid gland function. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 50(8): 2774-2779, 2012

The effect of PGI2 analogue on vascular endothelial function and platelet aggregation in patients with NIDDM. Journal of Diabetes and its Complications 9(4): 330-333, 1995

Effect of genistein and raloxifene on vascular dependent platelet aggregation. Molecular and Cellular Endocrinology 267(1-2): 55-62, 2007

Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris. Terapevticheskii Arkhiv 72(8): 24-27, 2000

No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. American Heart Journal 145(3): E15, 2003

Effects of phytoestrogens genistein and daidzein on prostacyclin production by human endothelial cells. Journal of Pharmacology and Experimental Therapeutics 315(2): 722-728, 2005