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Effect of inhibitors of cell signal transduction on egg granuloma formation in mice infected with Schistosoma japonicum


Effect of inhibitors of cell signal transduction on egg granuloma formation in mice infected with Schistosoma japonicum



Chinese Journal of Parasitology and Parasitic Diseases 20(6): 335-338



ISSN/ISBN: 1000-7423

A study was carried out to observe the effect of signalling inhibitors of tyrosine protein kinase (TPK), protein kinase C (PKC) and phosphatidylinositol-3-kinase (PI3-K) (tyrphostin-25, D-sphingosine and wortmannin, respectively) on the egg granuloma formation of Schistosoma japonicum and probe the mechanism of the effect. Three signalling inhibitors were injected to the tail vein of mice on day 35 after infection for 5 successive days.

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Accession: 003729876

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