+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401



Effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401



Journal of Acquired Immune Deficiency Syndromes 27(2): 153-160



The effect of ritonavir 400 mg/saquinavir 400 mg twice daily on the stereoselective pharmacokinetics of methadone was examined in 12 HIV-infected, methadone-using study subjects. Design: A 24-hour methadone pharmacokinetic study was performed before antiretroviral therapy was begun and after 15 days of therapy. Methadone concentration was measured by a chiral plasma assay because the drug is administered as a racemic mixture of R- and S-methadone, but only the R-isomer is active.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003733757

Download citation: RISBibTeXText

PMID: 11404537

DOI: 10.1097/00126334-200106010-00010


Related references

The tolerability and pharmacokinetics of N-butyl-deoxynojirimycin in patients with advanced HIV disease (ACTG 100). The AIDS Clinical Trials Group (ACTG) of the National Institute of Allergy and Infectious Diseases. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 10(5): 549-553, 1995

Effect of saquinavir/ritonavir (1000/100 mg bid) on the pharmacokinetics of methadone in opiate-dependent HIV-negative patients on stable methadone maintenance therapy. Addiction Biology 14(3): 321-327, 2009

Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230. Clinical Infectious Diseases 60(10): 1552-1558, 2016

Pharmacokinetics and pharmacodynamics of thalidomide in HIV patients treated for oral aphthous ulcers: ACTG protocol 251. AIDS Clinical Trials Group. Journal of Clinical Pharmacology 41(10): 1091-1097, 2001

Effect of zidovudine resistance mutations on virologic response to treatment with zidovudine-lamivudine-ritonavir: genotypic analysis of human immunodeficiency virus type 1 isolates from AIDS clinical trials group protocol 315.ACTG Protocol 315 Team. Journal of Infectious Diseases 181(2): 491-497, 2000

Establishment of a quality assurance program for human immunodeficiency virus type 1 DNA polymerase chain reaction assays by the AIDS Clinical Trials Group. ACTG PCR Working Group, and the ACTG PCR Virology Laboratories. Journal of Clinical Microbiology 31(12): 3123-3128, 1993

Enrollment in parallel track studies of dideoxyinosine ddl vs aids clinical treatment group actg trials at san francisco california usa general hospital an actg site. Sixth International Conference on Aids Sixth International Conference on Aids, Vols 1-3 Pagination Varies Sixth International Conference on Aids University Of California San Francisco: San Francisco, California, Usa Illus Maps Paper : abstract Sd789, 1990

Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS Clinical Trials Group Study 359. Journal of Infectious Diseases 182(5): 1375-1384, 2000

Measurement of induced cytokines in AIDS clinical trials using whole blood: a preliminary report. ACTG Inducible Cytokines Focus Group. AIDS Clinical Trials Group. Clinical and Diagnostic Laboratory Immunology 5(4): 556-560, 1998

Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG A5202. Journal of Infectious Diseases 203(12): 1791-1801, 2011

The effects of once-daily saquinavir/minidose ritonavir on the pharmacokinetics of methadone. Journal of Clinical Pharmacology 44(3): 293-304, 2004

Associations of inflammatory markers with AIDS and non-AIDS clinical events after initiation of antiretroviral therapy: AIDS clinical trials group A5224s, a substudy of ACTG A5202. Journal of Acquired Immune Deficiency Syndromes 65(2): 167-174, 2014

Resistance mutations to zidovudine and saquinavir in patients receiving zidovudine plus saquinavir or zidovudine and zalcitabine plus saquinavir in AIDS clinical trials group 229. Journal of Infectious Diseases 179(1): 249-253, 1998

Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. British Journal of Clinical Pharmacology 52(3): 255-264, 2001

Pharmacokinetics of once daily saquinavir/ritonavir Effects on unbound methadone and alpha1-acid glycoprotein. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 14-15, 2001