+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Enhanced uptake of modified low-density lipoprotein by eicosapentaenoic acid-treated THP-1 macrophages



Enhanced uptake of modified low-density lipoprotein by eicosapentaenoic acid-treated THP-1 macrophages



Nutritional Sciences 4(1): 26-33



Animal and clinical studies as well as epidemiological data have provided convincing evidence that n-3 polyunsaturated fatty acids can protect against atherosclerosis. However, the effects of the fatty acids on atherogenesis are contradictory. This discrepancy could derive from great susceptibility of the fatty acids to oxidation. We investigated the effect of eicosapentaenoic acid (EPA) on cellular atherogenesis via the scavenger receptor of THP-1 derived macrophages.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 003751263

Download citation: RISBibTeXText


Related references

Enhanced uptake of elastase modified low density lipoprotein by human monocyte derived macrophages. American Heart Association Monograph (124): II-376, 1986

Beta-Galactosidase-modified low density lipoprotein demonstrates increased susceptibility to lipid peroxidation and enhanced uptake by macrophages. Israel Journal of Medical Sciences 30(12): 905-907, 1994

Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46(11): 1053-1061, 2011

Endocytosis of acetylated low density lipoprotein endothelial cell modified low density lipoprotein and formaldehyde treated serum albumin by rat liver endothelial cells evidence of uptake via a common receptor. Scandinavian Journal of Gastroenterology 22(10): 1263-1269, 1987

Reduced uptake of cholesterol esterase-modified low density lipoprotein by macrophages. Journal of Biological Chemistry 266(18): 11567-11574, 1991

Modification of low density lipoproteins by polymorphonuclear cell elastase leads to enhanced uptake by human monocyte-derived macrophages via the low density lipoprotein receptor pathway. Journal of Lipid Research 29(6): 797-808, 1988

Involvement of beta 2-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages. Clinical and Experimental Immunology 107(3): 569-573, 1997

The phosphoinositide 3-kinase signaling pathway is involved in the control of modified low-density lipoprotein uptake by human macrophages. Lipids 50(3): 253-260, 2015

Cilostazol inhibits modified low-density lipoprotein uptake and foam cell formation in mouse peritoneal macrophages. Atherosclerosis 204(2): 405-411, 2009

Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes-macrophages by enhanced production of ROS, TNF-α, MMP-9, and MMP-2. Molecular and Cellular Biochemistry 366(1-2): 277-285, 2012

Enhanced lipoprotein lipase secretion from human monocyte derived macrophages caused by uptake of hypertriglyceridemic very low density lipoproteins. Arteriosclerosis 8(5): 561A-562A, 1988

Different effects of chenodeoxycholic acid and ursodeoxycholic acid on low density lipoprotein receptor dependent and low density lipoprotein receptor independent uptake of low density lipoprotein in the hamster with an intact enterohepatic circulation. Hepatology 5(5): 985, 1985

Selective uptake of high-density lipoprotein-associated cholesteryl esters and high-density lipoprotein particle uptake by human monocyte-macrophages. Atherosclerosis 105(2): 145-157, 1994