Expression and regulation of cytosolic prostaglandin E synthase in mouse uterus during the peri-implantation period
Ni, H.; Sun, T.; Ma, X-Hong.; Yang, Z-Ming.
Biology of Reproduction 68(3): 744-750
Prostaglandin E2 (PGE2) is considered important for blastocyst spacing, implantation and decidualization in rodent uteri. PGE synthase (PGES) catalyses the isomerization of PGH2 to PGE2. Two isoforms of PGES exist: microsomal PGES (mPGES) and cytosolic PGES (cPGES); however, the expression and regulation of cPGES in the mammalian uterus during early pregnancy are still unknown.