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Glutathione metabolism and antioxidant enzymes in children with Down syndrome



Glutathione metabolism and antioxidant enzymes in children with Down syndrome



Journal of Pediatrics 142(5): 583-585



Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

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Accession: 003787585

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PMID: 12756395

DOI: 10.1067/mpd.2003.203


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