EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria


, : Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria. Acta Tropica 86(1): 55-62

Human basophils are potent producers of IL-4 following cross-linking of the high affinity receptor for IgE (Fc epsilon R1). Elevated levels of both total- and malaria-specific IgE have been demonstrated in sera from people living in malaria-endemic regions. Whether or not these IgE antibodies are pathogenic is unclear. Serum containing high IgE levels obtained from malaria individuals was used to establish whether IgE-immune complexes could induce IL-4 production in human basophils. The basophils, obtained from healthy donors, were primed with 10 ng/ml of IL-3 before being transferred to wells containing goat anti-human IgE or human antimalarial IgE-immune complexes. IL-4 was induced upon stimulation of human basophils by plate bound IgE-containing immune complexes. Basophils treated similarly but with goat anti-IgG/human antimalarial- IgG-immune complexes did not secrete IL-4. Similarly mononuclear cells depleted of basophils in parallel culture did not secrete IL-4. Thus, human basophils may contribute to the polarization of T-helper type 2 in the (Th2) responses in malaria hosts via IgE-induced IL-4 production.

Accession: 003803312

PMID: 12711103

DOI: 10.1016/s0001-706x(03)00005-6

Download PDF Full Text: Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Nyakeriga, M.A.; Troye-Blomberg, M.; Bereczky, S.; Perlmann, H.; Perlmann, P.; ElGhazali, G., 2003: Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria. Human basophils are potent producers of IL-4 following cross-linking of the high affinity receptor for IgE (Fc epsilon R1). Elevated levels of both total- and malaria-specific IgE have been demonstrated in sera from people living in malaria-endemi...

Fagan, D.L.; Slaughter, C.A.; Capra, J.D.; Sullivan, T.J., 1982: Monoclonal antibodies to immunoglobulin G4 induce histamine release from human basophils in vitro. Monoclonal murine antibodies to human IgE, IgG1, IgG2, IgG3, IgG4, IgM, and IgA1 were prepared and their abilities to stimulate histamine release from human peripheral blood leukocytes were investigated. As expected, anti-IgE caused 8% to 76% hist...

Thomas L.L., 1985: Enhancement of antigen stimulated histamine release from human basophils by immunoglobulin g immune complexes. Federation Proceedings: 1322

Devouassoux, G.; Saxon, A.; Metcalfe, D.D.; Prussin, C.; Colomb, M.G.; Brambilla, C.; Diaz Sanchez, D., 2002: Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils. Background: An epidemiologic relationship between airway allergic diseases and exposure to atmospheric pollutants has been demonstrated and suggested to be one factor in the increasing prevalence of asthma. Diesel exhaust particles (DEPs) have bee...

Devouassoux, G.; Saxon, A.; Metcalfe, D.D.; Prussin, C.; Colomb, M.G.; Brambilla, C.; Diaz-Sanchez, D., 2002: Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils. An epidemiologic relationship between airway allergic diseases and exposure to atmospheric pollutants has been demonstrated and suggested to be one factor in the increasing prevalence of asthma. Diesel exhaust particles (DEPs) have been shown to p...

Daha M.R.; Klar Mohamad N.; Van E.L.A., 1987: Synergistic effect of anti cr1 and c1q bearing igm complexes aigm c1q on immunoglobulin ig production by human peripheral lymphocytes. Complement 4(3-4): 144

Pruzansky J.J.; Patterson R., 1986: Binding constants of immunoglobulin e receptors on human blood basophils for immunoglobulin e. The ability to remove receptor-bound IgE but maintain functional integrity of human blood basophils allowed measurement of several parameters of binding of IgE. Non-specific binding was determined by a modification of the standard technique and wa...

Tanizaki Y.; Komagoe H.; Sudo M.; Kitani H.; Tada S.; Takahashi K.; Kimura I., 1984: Inhibitory effect of histamine gamma globulin conjugate on immunoglobulin e mediated reactivity of human basophils. Histamine-.gamma.=globin conjugate (HG) significantly inhibited IgE-mediated human basophil reactivity (histamine release and morphological changes). HG at concentrations ranging from 0.5-2.5 mg/ml inhibited histamine release from basophils induce...

Yamada, K.; Ikeda, I.; Maeda, M.; Shirahata, S.; Murakami, H., 1990: Effect of immunoglobulin production stimulating factors in foodstuffs on immunoglobulin production of human lymphocytes. Agricultural and Biological Chemistry 54(4): 1087-1089

Chyrek Borowska S.; Kuczewska B.; Hofman J.; Szymanski W.; Lukaszewicz D., 1985: The effect of short term immunotherapy with pollinex on anti immunoglobulin e and antigen induced histamine release from sensitive human basophils. Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine a...