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Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria

, : Immunoglobulin E (IgE) containing complexes induce IL-4 production in human basophils: effect on Th1-Th2 balance in malaria. Acta Tropica 86(1): 55-62

Human basophils are potent producers of IL-4 following cross-linking of the high affinity receptor for IgE (Fc epsilon R1). Elevated levels of both total- and malaria-specific IgE have been demonstrated in sera from people living in malaria-endemic regions. Whether or not these IgE antibodies are pathogenic is unclear. Serum containing high IgE levels obtained from malaria individuals was used to establish whether IgE-immune complexes could induce IL-4 production in human basophils. The basophils, obtained from healthy donors, were primed with 10 ng/ml of IL-3 before being transferred to wells containing goat anti-human IgE or human antimalarial IgE-immune complexes. IL-4 was induced upon stimulation of human basophils by plate bound IgE-containing immune complexes. Basophils treated similarly but with goat anti-IgG/human antimalarial- IgG-immune complexes did not secrete IL-4. Similarly mononuclear cells depleted of basophils in parallel culture did not secrete IL-4. Thus, human basophils may contribute to the polarization of T-helper type 2 in the (Th2) responses in malaria hosts via IgE-induced IL-4 production.

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Accession: 003803312

PMID: 12711103

DOI: 10.1016/s0001-706x(03)00005-6

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Mousa, S.A.; Mu, D.X.; Hussain, M., 1997: Intranasal antiplatelet/antithrombotic efficacy of the platelet GPIIb/IIIa antagonist, DMP754. Journal of the American College of Cardiology 29(2 SUPPL A): 154A

Pinsky, L.; Kaufman, M.; Levitsky, L.L., 1987: Partial androgen resistance due to a distinctive qualitative defect of the androgen receptor. Using whole genital skin fibroblasts, we have characterized a novel androgen receptor mutation in a family with partial androgen resistance. The proposita was born with bilateral labioscrotal folds and a single perineal urogential orifice. Her sim...

Malabarba, LR., 1989: Historico sistematico e lista comentada das especies de peixes de agua doce do sistema da laguna dos Patos, Rio Grande do Sul, Brasil. Comunicacoes do Museu de Ciencias da PUCRGS Serie Zoologia, 28: 107-179

Nath, A.R.; Joshi, V.R.; Sainani, G.S., 1987: Tuberculosis--is immunological diagnosis feasible?. Journal of the Association of Physicians of India 35(11): 749-750

Rainsford, K.D.; Whitehouse, M.W., 1976: Concerning the merits of copper aspirin as a potential anti-inflammatory drug. Journal of Pharmacy and Pharmacology 28(1): 83-86

Dai, C.Y.; Haqq, C.M.; Puzas, J.Edward., 2006: Molecular correlates of site-specific metastasis. Metastasis is the spread of tumor cells from a primary site to distant organs. It is the major cause of cancer morbidity and death. In the last few decades, significant advances have been made in surgical techniques, radiation therapy delivery, an...

Cherchi, A.; Raffo, M.; Bina, M.; Fonzo, R.; Maxia, G.; Esu, M.P., 1971: Objective evaluation of the therapeutic activity of iproveratril. Minerva Cardioangiologica 19(3): 123-132

Reed, T. W., 1935: The Biology of the Apple Aphids in Relation to Fall Spraying. In the autumn of 1929 a study of Aphis pomi, DeG., Anuraphis roseus, Baker, and Rhopalosiphum prunifoliae, Fitch, on apple was begun in New York State. It was found that the autumn activities of these Aphids are independent of each other and that...

Curtin, L.L., 1986: The case of the reluctant role model: from health to heresy. Nursing Management 17(7): 7-8

Zolotarev, I.I., 1967: Diagnostic value of radioisotope studies in urolithiasis. Meditsinskaia Radiologiia 12(12): 37-42