Section 4
Chapter 3,808

In vitro and in vivo activities of gatifloxacin against Mycobacterium tuberculosis

Alvirez-Freites, E.J.; Carter, J.L.; Cynamon, M.H.

Antimicrobial Agents and ChemoTherapy 46(4): 1022-1025


ISSN/ISBN: 0066-4804
PMID: 11897584
DOI: 10.1128/aac.46.4.1022-1025.2002
Accession: 003807448

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Gatifloxacin (GAT) and moxifloxacin (MXF) were evaluated in vitro to determine their activities against M. tuberculosis. GAT was subsequently compared in a dose range study to isoniazid (INH) in a murine tuberculosis model. GAT was somewhat less active than INH. GAT and MXF were evaluated in mice infected with M. tuberculosis and were found to have similar activities.

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