EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical






Neurochemistry International 42(5): 401-407

Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical

The intraplantar injection of dehydroepiandrosterone sulfate (DHEAS), a representative neurosteroid, showed hyperalgesia in the Hargreaves' thermal or automatic paw-pressure mechanical nociception test. The DHEAS-induced hyperalgesia was abolished by diphenhydramine (DPH), a H(1) histamine (His) receptor antagonist, as well as the hyperalgesia induced by His or compound 48/80, a mast cell degranulating agent. The DHEAS-induced hyperalgesia was also blocked by progesterone (PROG), another type of neurosteroid and a putative neurosteroid receptor antagonist. Neither DPH nor PROG showed any changes in the thermal threshold. On the other hand, endocrine disrupting chemicals (EDCs) are known to disrupt reproductive system in wild-lives and humans through the disturbance of the endocrine homeostasis. In this study, the flexor responses induced by intraplantar injection of DHEAS were blocked by p,p'-DDE, an EDC as well as by PROG in the algogenics-induced nociceptive flexor responses test (ANF test) in mice. Similarly, p,p'-DDE blocked the DHEAS-induced hyperalgesia in Hargreaves' thermal nociception test. Besides the hyperalgesic actions, DHEAS increased vascular permeability as measured with Evans blue plasma extravasation. Consistent with behavioral studies, it was blocked by DPH, PROG, and p,p'-DDE. These results suggest that DHEAS has significant hyperalgesic and vasodilatory actions through histamine release, and these actions were reversible by PROG and an EDC.

Accession: 003859392

PMID: 12510023

DOI: 10.1016/s0197-0186(02)00135-3

Download PDF Full Text: Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical



Related references

Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells. Toxicological Sciences 90(2): 362-368, 2005

Effects of endocrine-disrupting contaminants on amphibian oogenesis: Methoxychlor inhibits progesterone-induced maturation of Xenopus laevis oocytes in vitro. Environmental Health Perspectives 107(4): 285-292, April, 1999

Chemoprevention of rat mammary cancer induced by endocrine disrupting chemical after gamma-ray irradiation. Journal of Radiation Research 41(4): 446, December, 2000

Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquatic Toxicology 118-119: 108-115, 2012

Histamine induced prostaglandin e 2 release from canine tracheal smooth muscle is inhibited by h 2 receptor blockade. American Review of Respiratory Disease 137(4 PART 2): 373, 1988

Contribution of the Endocrine Perspective in the Evaluation of Endocrine Disrupting Chemical Effects: The Case Study of Pubertal Timing. Hormone Research in Paediatrics 86(4): 221-232, 2016

Incorporation of endocrine disruption into chemical hazard scoring for pollution prevention and current list of endocrine disrupting chemicals. Drug and Chemical Toxicology 24(4): 359-420, 2001

Mast cell secretion (histamine release) induced by 48-80: calcium-dependent exocytosis inhibited strongly by cytochalasin only when glycolysis is rate-limiting. Journal of Physiology 234(2): 97p-98p, 1973

Hormone-stimulated calcium release is inhibited by cytoskeleton-disrupting toxins in AR4-2J cells. Cell Calcium 28(2): 73-82, 2000

Mast cell secretion histamine release induced by compound 48 80 calcium dependent exocytosis inhibited strongly by cytochalasin only when glycolysis is rate limiting. Journal of Physiology (Cambridge) 234(2): 97-98, 1973