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Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

Oligonucleotide directed misfolding of RNA inhibits Candida albicans group I intron splicing

Proceedings of the National Academy of Sciences of the United States of America 99(17): 11091-6

RNA is becoming an important therapeutic target. Many potential RNA targets require secondary or tertiary structure for function. Examples include ribosomal RNAs, RNase P RNAs, mRNAs with untranslated regions that regulate translation, and group I and group II introns. Here, a method is described to inhibit RNA function by exploiting the propensity of RNA to adopt multiple folded states that are of similar free energy.

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Accession: 003868870

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PMID: 12169671

DOI: 10.1073/pnas.172391199

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