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Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine

Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine

Journal of Nutrition 133(9): 2857-2862

Biotin status and function are decreased during oral carbamazepine (CBZ) administration in both humans and rats, but it is not known whether biotin supplementation can prevent these decreases. To test the effectiveness of pharmacological biotin supplementation during CBZ administration, 55 rats were randomly divided into 4 groups (0.06 mg biotin/kg diet with or without 3.75 g CBZ/kg diet, and 6.0 mg biotin/kg diet with or without 3.75 g CBZ/kg diet).

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Accession: 003880761

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PMID: 12949377

DOI: 10.1093/jn/133.9.2857

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