+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate



Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate



Journal of Infectious Diseases 186(1): 138-140



The effects in vivo of the bisphosphonate drug pamidronate, used in bone resorption therapy, were investigated in an experimental model of cutaneous leishmaniasis. Pamidronate at an intraperitoneal dose of 10 mg/kg/day for 5 days effects a radical cure of cutaneous leishmaniasis in Balb/c mice, as evidenced by long-term disappearance of lesions; disappearance of amastigotes in lesion sites, as determined by histopathological analysis and cultivation of material obtained from lesions; and polymerase chain reaction analysis of necropsy material, using probes specific for kinetoplast DNA. Pamidronate is, therefore, a new lead compound for the synthesis of drugs effective against cutaneous leishmaniasis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003906004

Download citation: RISBibTeXText

PMID: 12089677

DOI: 10.1086/341074


Related references

Persistence of leishmania parasites in scars after clinical cure of American cutaneous leishmaniasis: is there a sterile cure?. Journal of Infectious Diseases 189(6): 1018-1023, 2004

The Bisphosphonate Pamidronate is an Intestinal Antiinflammatory Agent in Rat and Mouse Experimental Colitis. Inflammatory Bowel Diseases 22(11): 2549-2561, 2016

Experimental leishmaniasis. V. Reproduction in mice (Mus musculi, var. albina) of a nodulo-tumoral cutaneous leishmaniasis (leishmaniasis histocytoma) in the Amazon. Hospital 40(6): 919-931, 1951

Experimental leishmaniasis. IV. Reproduction in hamsters (Cricetus auratus) of a nodulo-tumoral cutaneous leishmaniasis of the Amazon (leishmaniasis histiocytoma). Hospital 40(5): 665-676, 1951

Cutaneous leishmaniasis (oriental sore). V. Experimental canine cutaneous leishmaniasis. Arch. Derm, Chicago, 51:, 1945

Cutaneous leishmaniasis in an AIDS patient: cure with itraconazole. Journal of Infectious Diseases 162(5): 1221-1222, 1990

Failure of rifampin therapy to cure cutaneous leishmaniasis. Archives of Dermatology 116(9): 988, 1980

Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis. Infection and Immunity 62(6): 2614-2618, 1994

Immunologic patterns associated with cure in human American cutaneous leishmaniasis. Brazilian Journal of Medical and Biological Research 31(1): 139-142, 1998

Experimental cutaneous leishmaniasis: disseminated leishmaniasis in genetically susceptible and resistant mice. American Journal of Tropical Medicine and Hygiene 31(2): 230-238, 1982

Experimental cutaneous leishmaniasis. II. The pathology of leishmaniasis by Leishmania mexicana. Revista do Instituto de Medicina Tropical de Sao Paulo 7(3): 145-155, 1965

Leishmaniasis: experimental studies of visceral and cutaneous leishmaniasis. Recent Advances in Tropical Medicine (1): 102-113, 1984

Delayed skin healing of cutaneous leishmaniasis after clinical cure of mucosal surfaces. Revista Da Sociedade Brasileira de Medicina Tropical 29(3): 285-285, 1996