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Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats

Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats

American Journal of Hypertension 15(2): 157-163

The role of L- and D-isomers of homocysteine (Hcy) in vascular versus endocardial endothelial (EE) remodeling and function is not well understood. The hypothesis is that Hcy decreases EE cell density by activating matrix metalloproteinase (MMP) and by inducing left ventricular hypertrophy (LVH) in homocysteinemic hypertensive rats (HHR). And L- and D-isomers of Hcy have differential effects in vessel and myocardium.

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Accession: 003919918

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PMID: 11863251

DOI: 10.1016/s0895-7061(01)02286-5

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