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Reversal of mefloquine and quinine resistance in Plasmodium falciparum with NP30



Reversal of mefloquine and quinine resistance in Plasmodium falciparum with NP30



Antimicrobial Agents and ChemoTherapy 47(8): 2393-2396



Quinoline resistance in malaria is frequently compared with P-glycoprotein-mediated multidrug resistance (mdr) in mammalian cells. We have previously reported that nonylphenolethoxylates, such as NP30, are potential Plasmodium falciparum P-glycoprotein substrates and drug efflux inhibitors. We used in vitro assays to compare the ability of verapamil and NP30 to sensitize two parasite isolates to four quinolines: chloroquine (CQ), mefloquine (MF), quinine (QN), and quinidine (QD).

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Accession: 003919921

Download citation: RISBibTeXText

PMID: 12878495

DOI: 10.1128/aac.47.8.2393-2396.2003


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