+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Sequence of the 3'-terminal end (8.1 kb) of the genome of porcine haemagglutinating encephalomyelitis virus: comparison with other haemagglutinating coronaviruses



Sequence of the 3'-terminal end (8.1 kb) of the genome of porcine haemagglutinating encephalomyelitis virus: comparison with other haemagglutinating coronaviruses



Journal of General Virology 83(Pt 10): 2411-2416



A cytopathogenic coronavirus, serologically identified as porcine haemagglutinating encephalomyelitis virus (HEV), has recently been associated with acute outbreaks of wasting and encephalitis in nursing piglets from pig farms in southern Quebec and Ontario, Canada. The 3'-terminal end of the genome of the prototype HEV-67N strain and that of the recent Quebec IAF-404 field isolate, both propagated in HRT-18 cells, were sequenced. Over-all, sequencing data indicated that HEV has remained antigenically and genetically stable since its first isolation in North America in 1962. Compared with the prototype strain of bovine enteropathogenic coronavirus (BCoV) , HEV, as well as the human respiratory coronavirus (HCoV-OC43} showed a major deletion in their ORF4 gene. Deduced amino acid sequences for both HEV strains revealed 89/88, 8O, 93/92 and 95/94% identities with the structural proteins HE, S, M and N of BCoV and HCoV-OC43, respectively. Major variations were observed in the S1 portion of the S gene of both HEV strains, with only 73/71% amino acid identities compared with those of the two other haemagglutinating coronaviruses.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 003930921

Download citation: RISBibTeXText

PMID: 12237422


Related references

Porcine coronaviruses in Austria. III. Haemagglutinating encephalomyelitis virus. Wiener Tierarztliche Monatsschrift 77(4): 117-120, 1990

Experimental infection of pigs with porcine haemagglutinating encephalomyelitis virus. Japanese Journal of Veterinary Science 51(4): 827-830, 1989

Identification of Porcine haemagglutinating encephalomyelitis virus receptor in PK cell membranes. Chinese Journal of Agricultural Biotechnology 5(1): 87-92, 2008

Inducement of cytopathic changes and plaque formation by porcine haemagglutinating encephalomyelitis virus. Veterinary Microbiology 8(6): 521-530, 1983

Serological survey for porcine haemagglutinating encephalomyelitis virus infection in pigs in Japan. Journal of the Japan Veterinary Medical Association 42(12): 867-870, 1989

Occurrence of antibodies to haemagglutinating encephalomyelitis and murine hepatitis coronaviruses in various species. Vorkommen von Antikorpern gegen hamagglutinierendes Encephalomyelitis Virus und Mause Hepatitis Virus bei verschiedenen Spezies: 80, 1985

The region between the M and S genes of porcine haemagglutinating encephalomyelitis virus is highly similar to human coronavirus OC43. Journal of General Virology 77: 1443-1447, 1996

Gene-expression patterns in the cerebral cortex of mice infected with porcine haemagglutinating encephalomyelitis virus detected using microarray. Journal of General Virology 95(Pt 10): 2192-2203, 2014

Comparative analysis of virus-host cell interactions of haemagglutinating and non-haemagglutinating strains of coxsackievirus B3. Journal of General Virology 80: 3153-3158, 1999

Studies on Intratypic Variants of Echoviruses. I. Separation of Haemagglutinating and Non-Haemagglutinating Virus Particles from Echovirus Type 6. Acta Microbiologica Academiae Scientiarum Hungaricae 10: 293-306, 1963

Apoptosis of granulocytes and lymphocytes in peripheral blood in rabbits infected with haemagglutinating and non-haemagglutinating antigenic variants of the RHD (rabbit haemorrhagic disease) virus. Polish Journal of Veterinary Sciences 16(2): 223-229, 2013

Haemagglutinating encephalomyelitis virus infection of pigs. Australian Veterinary Journal 55(10): 503-504, 1979

Haemagglutinating encephalomyelitis virus infection of pigs. Refresher course on pigs, March 9-13, 1981 Proceedings No56: 275-278, 1981

Neurotropism of mouse-adapted haemagglutinating encephalomyelitis virus. Journal of Comparative Pathology 109(1): 21-27, 1993

Encephalomyelitis of swine caused by a haemagglutinating virus. II. Virological studies. Res Vet Sci 4(4): 511-517, 1963