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Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans


Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans



Molecular Biology of the Cell 12(11): 3631-3643



ISSN/ISBN: 1059-1524

PMID: 11694594

DOI: 10.1091/mbc.12.11.3631

The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in the development of pathogenicity. We have cloned the CaCDC35 gene encoding C. albicans adenylyl cyclase by functional complementation of the conditional growth defect of Saccharomyces cerevisiae cells with mutations in Ras1p and Ras2p.

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