EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Spectrophotometric methods for the rapid determination of menadione and menadione sodium bisulphite and their application in pharmaceutical preparations


Spectrophotometric methods for the rapid determination of menadione and menadione sodium bisulphite and their application in pharmaceutical preparations



Journal of Pharmaceutical and Biomedical Analysis 28(1): 161-168



ISSN/ISBN: 0731-7085

PMID: 11861119

DOI: 10.1016/s0731-7085(01)00599-4

Two simple, rapid and sensitive spectrophotometric determination of menadione and its sodium bisulfite derivative (MSB) have been carried out. The first method involves the reaction of menadione and its sodium bisulfite derivative with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in sodium hydroxide medium to give a blue coloured product having maximum absorption at 625 nm and which is stable for more than one h. Beer's law is obeyed in the range 0.4-16 micro g/ml.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003941884

Download citation: RISBibTeXText

Related references

GC-FID and HPLC-DAD Methods for the Determination of Menadione Sodium Bisulphite Directly and by Converting Menadione Sodium Bisulphite to Menadione in Pharmaceutical Preparation. Iranian journal of pharmaceutical research: IJPR 13(2): 353-364, 2014

Spectrophotometric determination of menadione and menadione sodium bisulfite in pharmaceutical preparations. International Journal of Pharmaceutics 39(1-2): 137-140, 1987

Estimation of vitamin K activity by biological methods. 3. Comparison of the stability of menadione sodium bisulphite and menadione pyrimidinol bisulphite. Zeitschrift fur Tierphysiologie, Tierernahrung und Futtermittelkunde 34(6): 325-341, 1975

Comparison of gas liquid chromatographic and chemical methods for quantitative determination of the menadione and menadione sodium bi sulfite content of pharmaceutical products. Journal of the Association of Official Analytical Chemists 53(5): 1093-1096, 1970

Colorimetric method for the estimation of menadione or menadione sodium bi sulfite in pharmaceutical preparations. Indian Journal of Pharmacy 35(6): 200, 1973

Spectrophotometric determination of menadione and menadione sodium bi sulfite. Journal of the Association of Official Analytical Chemists 65(1): 141-143, 1982

Comparison of gas chromatographic calibration methods for analysis of menadione and menadione sodium bisulfite content of pharmaceutical products. Journal of the Association of Official Analytical Chemists 55(3): 660-661, 1972

Polarographic determination of menadione sodium bi sulfite in pharmaceutical preparations. Journal of the Association of Official Analytical Chemists 56(6): 1460-1463, 1973

Colorimetric method for the estimation of menadione or menadione sodium bi sulfite in pharmaceutical dosage forms. Indian Journal of Pharmacy 37(6): 141-143, 1975

Determination of menadione sodium bisulfite in pharmaceutical preparations by flow-injection on-line photochemical spectrofluorometry. Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry 17(10): 1209-1212, 2001

Determination of vitamin k menadione sodium bisulfite in pharmaceutical preparations and feed premixes by high pressure liquid chromatography. Indian Journal of Pharmaceutical Sciences 47(2): 60, 1985

Determination of menadione in pharmaceutical preparations. Indian Journal of Pharmaceutical Sciences 53(5): 219-221, 1991

Chemiluminescence analysis of menadione sodium bisulfite and analgin in pharmaceutical preparations and biological fluids. Journal of Pharmaceutical and Biomedical Analysis 21(4): 817-825, 1999

Fluorimetric determination of menadione sodium bisulphite (vitamin K3) in animal feed and premixes by high-performance liquid chromatography with post-column derivatization. Journal of Chromatography 301(2): 441-447, 1984

Determination of vitamin k activity with the bioassay part 3 stability of menadione sodium bi sulfite and menadione di methyl pyrimidinol bi sulfite. Zeitschrift fuer Tierphysiologie Tierernaehrung und Futtermittelkunde 34(6): 325-341, 1975