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Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity



Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity



Endocrinology 142(11): 4599-4606



STAT5 transduces transcriptional responses to GH in liver and other tissues and is proposed to mediate the sexually dimorphic effects of plasma GH secretory profiles on rodent liver gene expression. Previous studies have suggested that STAT5 undergoes repeated activation in direct response to successive GH pulses in adult male rats, with STAT5 activation being desensitized in females by their more persistent pattern of GH exposure.

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Accession: 003959480

Download citation: RISBibTeXText

PMID: 11606424

DOI: 10.1210/endo.142.11.8480


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