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The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine

The abundance and function of biotin-dependent enzymes are reduced in rats chronically administered carbamazepine

Journal of Nutrition 132(11): 3405-3410

The effect of dietary antiepileptic drug administration on the metabolism and function of the water-soluble vitamin biotin was analysed in a physiologically relevant rat model of biotin nutriture. Administration of carbamazepine (CBZ) in semipurified rat diet at 1.5 and 2.9 g/kg for 19 d did not reduce growth rate or food intake. After this dietary treatment, brain lactic acid and ammonia concentrations were significantly elevated, but no changes in these metabolites occurred in the liver.

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Accession: 003962698

Download citation: RISBibTeXText

PMID: 12421859

DOI: 10.1093/jn/132.11.3405

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