+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

The effects of gamma interferon on replication of foot-and-mouth disease virus in persistently infected bovine cells

The effects of gamma interferon on replication of foot-and-mouth disease virus in persistently infected bovine cells

Archives of Virology 147(11): 2157-2167

ISSN/ISBN: 0304-8608

PMID: 12417950

DOI: 10.1007/s00705-002-0867-6

Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of cloven-hoofed animals, which has a considerable socio-economic impact on the countries affected. In addition, persistent infection can occur following clinical or sub-clinical disease in either vaccinated or non-vaccinated cattle. The mechanism(s) by which FMDV persistence is established and maintained is not fully understood. To better understand the basic mechanisms controlling the virus infection in cattle, the effects of interferon gamma (IFN-gamma) on the replication of FMDV was evaluated in vitro in persistently infected-epithelial cells isolated from FMDV infected cattle. Initially primary bovine thyroid (BTY) cells were treated with varying doses of bovine recombinant IFN-gamma. The cytokine activity was measured by detection of viral antigen in cell supernatants and viral RNA expression compared with cells without INF-gamma treatment. Pretreatment with IFN-gamma profoundly affected FMDV growth in BTY cells. The replication of FMDV was affected in the presence of more than 2.5 u/ml of IFN-gamma and the effect was both dose-dependent and related to the time of exposure. Analysis of the mechanism of inhibition suggests that IFN-gamma did not inhibit the viral replication through induction of nitric oxide. More interesting is the finding that continuous treatment with IFN-gamma severely restricts FMDV replication or even cures persistently infected bovine epithelial cells, indicating that a cytokine-mediated pathway may be involved in the in vivo clearance of persistent FMDV.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003970534

Download citation: RISBibTeXText

Related references

Antigenic analysis of type O foot-and-mouth disease virus in the persistently infected bovine. Archives of Virology 141(8): 1407-1421, 1996

Ultrastructural and replicative features of foot-and-mouth disease virus in persistently infected BHK-21 cells. Archives of Virology 140(1): 13-25, 1995

Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis. Virology 311(2): 339-349, 2003

Rapid selection of the cells persistently infected with Foot-and-mouth disease virus and the study of natures in persistent infection cells. Virologica Sinica 18(5): 459-463, 2003

A study of replication of foot-and-mouth disease virus in infected cells. Veterinariia 45(7): 22-23, 1968

Alpha/beta interferon promotes transcription and inhibits replication of borna disease virus in persistently infected cells. Journal of Virology 75(17): 8216-8223, 2001

Genome sequence of foot-and-mouth disease virus outside the 3A region is also responsible for virus replication in bovine cells. Virus Research 220: 64-69, 2016

The ultrastructure of the developing replication site in foot-and-mouth disease virus-infected BHK-38 cells. Journal of General Virology 85(Pt 4): 933-946, 2004

Expression of bovine Mx1 protein inhibits the replication of foot-and-mouth disease virus in BHK-21 cells. Acta Virologica 57(4): 429-434, 2013

Establishment of cell lines persistently infected with foot-and-mouth disease virus. Virology 145(1): 24-35, 1985

The effect of interferon and guanidine on the inactivation of RNA of foot-and-mouth disease virus infected cells. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 354(10-11): 1164-1165, 1973

The foot-and-mouth disease virus cis-acting replication element (cre) can be complemented in trans within infected cells. Journal of Virology 77(3): 2243-2246, 2003

Effects of interferon, ribavirin, and iminosugar derivatives on cells persistently infected with noncytopathic bovine viral diarrhea virus. Antimicrobial Agents and ChemoTherapy 48(2): 497-504, 2004

Infectious bovine rhinotracheitis virus vector that expresses foot-and-mouth disease virus epitopes on the surface of viral particles and virus-infected cells. Vaccines 91 Modern approaches to new vaccines including prevention of AIDS: 327-331, 1991

Foot and mouth disease virus replication in bovine skin Langerhans cells under in vitro conditions detected by RT-PCR. Virus Genes 10(1): 5-13, 1995