+ Site Statistics
References:
52,572,879
Abstracts:
28,705,754
PMIDs:
27,750,366
DOIs:
25,464,004
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection



A mutation in the latency-related gene of bovine herpesvirus 1 inhibits protein expression from open reading frame 2 and an adjacent reading frame during productive infection



Journal of Virology 78(6): 3184-3189



The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5' terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or an adjacent reading frame that lacks an initiating ATG (reading frame C). Since the LR mutant and wild-type BHV-1 express similar levels of LR RNA, we conclude that LR protein expression plays an important role in regulating the latency reactivation cycle in cattle.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 004018827

Download citation: RISBibTeXText

PMID: 14990740

DOI: 10.1128/jvi.78.6.3184-3189.2004


Related references

Open reading frame 2, encoded by the latency-related gene of bovine herpesvirus 1, has antiapoptotic activity in transiently transfected neuroblastoma cells. Journal of Virology 82(21): 10940-5, 2008

New mechanism in translational inhibition of upstream open reading frame for main open reading frame in SAMDC gene expression. Plant Biology (Rockville) : 133, 2000

Human herpesvirus 8 open reading frame 26 and open reading frame 65 sequences from multiple myeloma patients: a shared pattern not found in Kaposi's sarcoma or primary effusion lymphoma. Clinical Cancer Research 6(11): 4226-4233, 2000

The bovine herpesvirus type 1 UL3.5 open reading frame encodes a virion structural protein. Virology 240(1): 76-82, 1998

A protein encoded by the bovine herpesvirus 1 open reading frame E gene induces neurite-like morphological changes in mouse neuroblastoma cells and is expressed in trigeminal ganglionic neurons. Journal of Neurovirology 13(2): 139-149, 2007

The conserved open reading frame overlapping the thymidine kinase gene of different herpesviruses exists also in bovine herpesvirus 1. Acta Veterinaria Hungarica 37(4): 361-364, 1989

Expression of the open reading frame 74 gene of Kaposis sarcoma -associated herpesvirus Implications for KS pathogenesis. Journal of Virology 73(7): 6006-6014, 1999

The Herpesvirus Saimiri open reading frame 73 gene product interacts with the cellular protein p32. Journal of Virology 76(22): 11612-11622, 2002

Expression of human herpesvirus 8 (HHV-8)-encoded immediate early protein, open reading frame 50, in HHV-8-associated diseases. Journal of Human Virology 4(2): 96-102, 2001

Effects of codon-optimization on protein expression by the human herpesvirus 6 and 7 U51 open reading frame. Journal of Virological Methods 111(2): 145-156, 2003

The open reading frame (ORF) 50a gene product regulates ORF 57 gene expression in herpesvirus saimiri. Journal of Virology 72(3): 1967-1973, 1998

An inhibitory effect of the sequence-conserved upstream open reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis. 2012

An inhibitory effect of the sequence-conserved upstream open-reading frame on the translation of the main open-reading frame of HsfB1 transcripts in Arabidopsis. Plant, Cell and Environment 35(11): 2014-2030, 2013

The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochemical and Biophysical Research Communications 424(3): 469-475, 2012

A novel protein encoded by Kaposi's sarcoma-associated herpesvirus open reading frame 36 inhibits cell spreading and focal adhesion kinase activation. Intervirology 50(6): 426-432, 2008