+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation

Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation

Neurochemistry International 44(8): 579-584

Neurochemical alterations of markers related to synaptic function are potential candidates for age-related impairment of brain function and cognition. The process of aging, including brain aging, can be counteracted to some degree by maintaining animals in long-term conditions of caloric restriction, or supplementing their diet with antioxidant substances. We report here that the age-related decline of the cholinergic and GABAergic systems, that takes place in some CNS regions of aged rats, is not affected by maintaining them under conditions of dietary restriction and, therefore, of reduced calorie intake, from the 12th to the 30th month of age. We also notice the same lack of effect by adding, during the same period, the aging rat diet with the potential antioxidant substance, N-acetylcysteine (NAC). The same dietary manipulations are also unable to counteract the derangement of the first step of the main biosynthetic pathway for polyamines, putative neuromodulators in the CNS, that occurs in the aged spinal cord. Some age-related alterations in the expression of different subunits of the NMDA-type glutamate receptors in some CNS regions of aged rats were instead, at least in some cases, counteracted by long-term dietary manipulation.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 004033672

Download citation: RISBibTeXText

PMID: 15016472

DOI: 10.1016/j.neuint.2003.10.007

Related references

Effects of long term alterations of dietary calcium and magnesium on indices of rat brain aging and bone structure. Ingram, D K , G T Baker, Iii And N W Shock (Ed ) American Health Foundation Series: The Potential For Nutritional Modulation Of Aging Processes; International Conference, New York, New York, Usa, September 13-15, 1988 Xiii+417p Food And Nutrition Press, Inc : Trumbull, Connecticut, Usa Illus 327-342, 1991

Aging with traumatic brain injury: long-term health conditions. International Journal of Rehabilitation Research. Internationale Zeitschrift für Rehabilitationsforschung. Revue Internationale de Recherches de Readaptation 27(3): 209-214, 2004

Inflammation and brain function under basal conditions and during long-term elevation of brain corticotropin-releasing hormone levels. Advances in Experimental Medicine and Biology 461: 129-152, 1999

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers. Biochimica et Biophysica Acta 1852(8): 1665-1675, 2015

Coronary blood flow and mechanical activity of the left ventricle under normal conditions and in long term myo cardial hyper function. Biologicheskie Nauki 19(1): 75-80, 1976

Long-term Conditions Sue Randall Long-term Conditions and Helen Ford (Eds) Wiley-Blackwell £26.99 324pp 9781444332490 144433249X [Formula: see text. Emergency Nurse 19(7): 11-11, 2011

Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3). Eneuro 2(5):, 2015

Long-term exposure to environmental enrichment since youth prevents recognition memory decline and increases synaptic plasticity markers in aging. Neurobiology of Learning and Memory 90(3): 511-518, 2008

Absence of long term effects of dietary manipulation before unilateral nephrectomy on renal function in rats. Kidney International 40(2): 345, 1991

Long-term experimental manipulation of moisture conditions and its impact on moss-living tardigrades. Journal of Limnology 66(Suppl. 1): 119-125, 2007

Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation. Hippocampus 12(6): 787-802, 2002

Effect of long-term dietary manipulation on the aggregation of rat lens crystallins: role of alpha-crystallin chaperone function. Molecular Vision 8: 298-305, 2002

Radiation-induced long-term alterations in hippocampus under experimental conditions. Klinicka Onkologie 25(2): 110-116, 2012

Blocking endocytosis enhances short-term synaptic depression under conditions of normal availability of vesicles. Neuron 80(2): 343-349, 2013

In vivo accumulation of some amino acids in the brain of the mouse under normal conditions and in experimental epilepsy part 1 in normal conditions. Bollettino Societa Italiana Biologia Sperimentale 48(21): (1973) 723-726, 1972