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Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies



Antifungal agents. 11. N-substituted derivatives of 1-[(aryl)(4-aryl-1H-pyrrol-3-yl)methyl]-1H-imidazole: synthesis, anti-Candida activity, and QSAR studies



Journal of Medicinal Chemistry 48(16): 5140-5153



1-((Aryl)(4-aryl-1H-pyrrol-3-yl)methyl)-1H-imidazoles were recently reported by our group as potent anti-Candida agents belonging to the antifungal azole class. In the present paper the synthesis, anti-Candida activities, and QSAR studies on a novel series of N-substituted 1-((aryl)(4-aryl-1H-pyrrol-3-yl)methyl)-1H-imidazole derivatives are reported.

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Accession: 004042530

Download citation: RISBibTeXText

PMID: 16078834

DOI: 10.1021/jm048997u


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