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Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models



Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models



Medical Mycology 43(2): 133-152



Non-parametric and parametric approaches of two competing zero-interaction theories - the Loewe additivity and the Bliss independence - were evaluated for analyzing the in vitro interactions of various antifungal drugs. Fifty-one data sets, derived from three drug combinations, tested in triplicate against 17 clinical yeast and mold isolates with a two-dimensional checkerboard microdilution technique, were selected to span from strong synergy to strong antagonism.

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Accession: 004048365

Download citation: RISBibTeXText

PMID: 15832557

DOI: 10.1080/13693780410001731547


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