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Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy

Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy

American Journal of Respiratory and Critical Care Medicine 170(9): 967-973

Genome scans for asthma have identified suggestive or significant linkages on 17 different chromosomes, including chromosome 12, region q13-23, housing the vitamin D receptor (VDR) gene. Through interaction with VDR, 1,25-dihydroxyvitamin D3 mediates numerous biological activities, such as regulation of helper T-cell development and subsequent cytokine secretion profiles.

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Accession: 004050479

Download citation: RISBibTeXText

PMID: 15282199

DOI: 10.1164/rccm.200403-412OC

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