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Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata



Complement inhibitor of C5 activation from the soft tick Ornithodoros moubata



Journal of Immunology 174(4): 2084-2091



Blood-feeding ticks must control C activation or be damaged by the host inflammatory response. We report the characterization and expression of a novel, relatively small, broad-acting C inhibitory protein (termed OmCI) from the soft tick Ornithodoros moubata. The native 17-kDa nonglycosylated protein inhibits both human and guineapig classical and alternative C activation pathways.

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Accession: 004084204

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PMID: 15699138

DOI: 10.4049/jimmunol.174.4.2084


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