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Complete cycles of bloodstream trypanosome RNA editing in vitro

Complete cycles of bloodstream trypanosome RNA editing in vitro

Rna 10(6): 914-920

RNA editing in kinetoplastid protists is required for the maturation of mitochondrial pre-mRNAs and occurs by protein-catalysed cycles of uridylate insertion and deletion. During the complex life cycle of Trypanosoma brucei this process is differentially regulated in the mammalian bloodstream and insect procyclic stages. Complementary guide RNAs (gRNAs) direct editing, but the abundance of these transcripts is not developmentally controlled.

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Accession: 004084278

Download citation: RISBibTeXText

PMID: 15146075

DOI: 10.1261/rna.5157704

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