+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity



Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity



Journal of Agricultural and Food Chemistry 50(5): 1063-1069



Phenolics from the American cranberry (Vaccinium macrocarpon) were fractionated into a series of proanthocyanidins and other flavonoid compounds by vacuum chromatography on a hydrophilic, porous polyvinylic gel permeation polymer. Antioxidant activity was not restricted to a particular class of components in the extract but was found in a wide range of the fractions. Significant chemopreventive activity, as indicated by an ornithine decarboxylase assay, was localized in one particular proanthocyanidin-rich fraction from the initial fractionation procedure. Further fractionation of the active anticarcinogenic fraction revealed the following components: seven flavonoids, mainly quercetin, myricetin, the corresponding 3-O-glycosides, (-)-epicatechin, (+)-catechin, and dimers of both gallocatechin and epigallocatechin types, and a series of oligomeric proanthocyanidins.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 004084671

Download citation: RISBibTeXText

PMID: 11853481

DOI: 10.1021/jf011136z


Related references

Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate -induced ornithine decarboxylase activity. Journal of Agricultural & Food Chemistry 50(5): 1063-1069, 2002

Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity. Archives of Pharmacal Research 22(6): 559-564, 1999

Inhibition of 12 o tetradecanoyl phorbol 13 acetate induced epidermal ornithine decarboxylase activity and tumor promotion by phospho lipase a 2 and lip oxygenase inhibitors. Japanese Journal of Pharmacology 33(Suppl.): 285P, 1983

Inhibition by epidermal extracts of the 12 o tetradecanoyl phorbol 13 acetate induced peak of ornithine decarboxylase ec 4.1.1.17 in mouse epidermis. Virchows Archiv B Cell Pathology Including Molecular Pathology 35(3): 229-238, 1981

Mechanism of inhibition by retinoic acid of the induction of a mouse epidermal ornithine decarboxylase activity by the tumor promoter 12 o tetradecanoyl phorbol 13 acetate. Proceedings of the American Association for Cancer Research & American Society of Clinical Oncology 22: 129, 1981

Epigenetic mechanism of tumor promotion. Interrelationship between inflammation and ornithine decarboxylase activity induced in vitro by the carcinogenic 12-O-tetradecanoyl-phorbol-13-acetate. Comptes Rendus de l'Academie des Sciences. Serie Iii Sciences de la Vie 307(5): 229-234, 1988

Effects of 3 iso butyl 1 methyl xanthine and cyclic nucleotides on 12 o tetradecanoyl phorbol 13 acetate induced ornithine decarboxylase ec 4.1.1.17 activity in mouse epidermis in vivo. Cancer Research 41(10): 3918-3926, 1981

Purification of 12 o tetradecanoyl phorbol 13 acetate induced ornithine decarboxylase ec 4.1.1.17 from mouse epidermis. International Journal of Biochemistry 15(7): 885-890, 1983

Glucose uptake and ornithine decarboxylase activity in tetradecanoyl phorbol acetate non-proliferative variants. Journal of Cellular Physiology 114(3): 317-320, 1983

Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis. Cancer Research 37(7 Pt 1): 2196-2201, 1977

Effect of asparaginase on tetradecanoyl phorbol 13 acetate induced ornithine decarboxylase in guinea pig keratinocytes in culture. Biology of the Cell 52(1 Part B): 34A, 1984

Studies of the induction of ornithine decarboxylase activity in primary cultures of adult rat hepatocytes by the phorbol ester 12-O-tetradecanoyl-13-acetate and other substances. Toxicology in Vitro 6(6): 589-596, 1992

Growth state dependent alterations in the ability of 12 o tetradecanoyl phorbol 13 acetate to increase ornithine decarboxylase ec 4.1.1.17 activity in reuber h 35 hepatoma cells. Cancer Research 41(9 Part 1): 3384-3391, 1981

Poly amine biosynthesis and skin tumor promotion inhibition of 12 o tetradecanoyl phorbol 13 acetate promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase ec 4.1.1.17 alpha di fluoromethyl ornithine. Biochemical and Biophysical Research Communications 105(3): 969-976, 1982

Effects of flavonoids and anti oxidants on 12 o tetradecanoyl phorbol 13 acetate caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lip oxygenase inhibition by these compounds. Gann 75(3): 214-222, 1984