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Compound load of copper and iron in the livers of pretreatment patients with Wilson's disease



Compound load of copper and iron in the livers of pretreatment patients with Wilson's disease



Journal of Trace Elements in Experimental Medicine 17(1): 65-74



Ceruloplasmin is a major ferroxidase in sera, and people with hypoceruloplasminemia might have iron load complications. We used histochemical and X-ray microanalysis techniques on pretreatment liver specimens from five patients with Wilson's disease. Serum levels of ceruloplasmin and ferritin were determined before chelation therapy. All the patients showed hypoceruloplasminemia ranging from 15 to 160 mg/L. Histo-chemical copper was positively stained in four of the five patients.

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Accession: 004084922

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DOI: 10.1002/jtra.10054


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