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Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus



Crystallization and preliminary crystallographic analysis of the fusion core from two new zoonotic paramyxoviruses, Nipah virus and Hendra virus



Acta Crystallographica. Section D, Biological Crystallography 60(Pt 6): 1161-1164



Highly conserved heptad-repeat (HR1 and HR2) regions in class I viral fusion (F) proteins, including the F protein from paramyxovirus, interact with each other post-fusion to form a six-helix bundle called a fusion core. Crystals of the fusion core of Nipah virus have been grown at 291 K using PEG 4000 as precipitant. The diffraction pattern of the crystal extends to 2.1 A resolution at 100 K in-house.

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Accession: 004092296

Download citation: RISBibTeXText

PMID: 15159588

DOI: 10.1107/s0907444904009515


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