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Degenerative joint disease in dogs. Part II. Characterization and pathogenesis



Degenerative joint disease in dogs. Part II. Characterization and pathogenesis



Zycie Weterynaryjne 80(4): 216-221



In osteoarthritis (OA) normal tissue turnover is disturbed. Tissue destruction occurs when proteinase-mediated degradation exceeds synthesis and is markedly influenced by cytokines and growth factors. Although cartilage degeneration characterizes osteoarthritis, changes also involve the participation of the synovial membrane and the subchondral bone. This review outlines current knowledge of factors that influence cartilage, synovial and subchondral bone biology.

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